CHICAGO — Nearly half of all male long-term survivors of childhood cancer who were treated with alkylating agents had normal sperm counts 20 years after treatment, but the rest were likely to have ...

NEW YORK, NY / ACCESSWIRE / October 24, 2017 / DelMar Pharmaceuticals, Inc. (DMPI) VAL-083, a novel alkylating agent that has demonstrated potency against brain tumor cells and can overcome resistance ...

Large Cleaved and Immunoblastic Lymphoma May Represent Two Distinct Clinicopathologic Entities Within the Group of Diffuse Large B-Cell Lymphomas t(4;14)-positive patients had a predominance of the ...

Please provide your email address to receive an email when new articles are posted on . Women who had childhood cancer may have an increased risk for premature ovarian insufficiency after treatment ...

Learn how ancestry changes genetic risk variants' impact on type 2 diabetes in childhood cancer survivors & alkylating agent exposure magnifies diabetes risk. Learn how ancestry changes genetic risk ...

SINCE the introduction of nitrogen mustard, methyl-bis-β-(chloroethyl)-amine, or HN 2 (Fig. 1), as a therapeutic agent in human cancer a number of analogues and related alkylating agents have been ...

Autologous transplants of P140K-expressing HSCs reduce hematopoietic toxicity of TMZ and benzylguanine therapy. Scientists report positive data from a first-in-man study evaluating the bone ...

Researchers have developed a dual catalyst system that directly installs alkyl groups -- fragments containing singly bonded carbon and hydrogen atoms that have extremely useful properties for drug ...

Therapy-related acute myeloid leukaemia (t-AML) is a late complication of chemotherapy and/or radiotherapy given for a primary disorder, usually a cancer, and represents upto 10% of all AML cases ...

Alkylating Agent Linked to Therapy-Related Leukemia For patients treated for Hodgkin's lymphoma (HL), cumulative doses of alkylating agent (AA) is associated with the risk of therapy-related acute ...

In contrast, we have previously reported the absence of such a pharmacodynamic relationship when busulfan is combined with other alkylating agents. 22 In that previous study, several high-dose ...

Large Cleaved and Immunoblastic Lymphoma May Represent Two Distinct Clinicopathologic Entities Within the Group of Diffuse Large B-Cell Lymphomas t(4;14)-positive patients had a predominance of the ...