What determines the fate of a T cell? Research highlights cellular 'housekeeping' mechanism

When killer T cells of our immune system divide, they normally undergo asymmetric cell division (ACD): Each daughter cell ...
eLife

Epidermal resident memory T cell fitness requires antigen encounter in the skin

Antigen-driven TCR signaling in the epidermis during CD8+ TRM differentiation results in a lower TGFβ requirement for persistence and increased proliferative capacity that together enhance epidermal ...
The Scientist

Aging Reprograms T Cell Behavior, Weakening Vaccine Responses

During vaccination, the immune system is purposefully exposed to weakened, inactivated, or a component of pathogens so that the body can recognize their molecular structures in the future and mount a ...
EurekAlert!

T cell-based cancer immunotherapy: Opportunities and challenges

CD8 + cytotoxic T lymphocytes (CTLs) serve as central effectors in cancer immunotherapy by directly eliminating tumor cells. However, current clinical therapies face significant limitations. These ...
Science Daily

New CAR-T Therapy achieves positive results in a high proportion of patients with a refractory type of lymphoma

A Phase I trial involving ten patients with relapsed or refractory classical Hodgkin lymphoma or T-cell lymphoma has achieved a 100% overall response rate and a 50% complete remission rate, in ...
Business Wire

VectorBuilder Powers FDA IND Approval of World’s First Umbilical Cord Blood-Derived Allogeneic CAR-T Product

UC101 is the world’s first FDA IND-approved umbilical cord blood-derived allogeneic CAR-T therapy. T cells derived from umbilical cord blood possess the natural advantages of low immunogenicity and ...
New Atlas

Non-brain cells can form memories, too

Memories can form outside of the brain, according to new research. Non-brain cells exposed to chemical pulses similar to the ones that brain cells are exposed to when presented with new information ...