Advanced Tools to Investigate All Compound Classes of GPCR Activation Among targets of interest for the pharmaceutical industry, GPCRs account for more than 30% of all drug screenings. The complexity ...

Scientists have uncovered a novel pathway by which hormones elevated in inflammation, cancer and cell injury act on cells to stimulate their growth. Many intracellular signaling proteins work as ...

Extracellular stimuli elicit cellular responses through generation of intracellular second messengers. The lipid second messenger diacylglycerol is produced following activation of the ...

A new study describes the development of a cAMP analogue that specifically activates only Epac2, one of several cAMP-responsive proteins. Furthermore, the analogue activates Epac2 more potently than ...

Extracellular signals are relayed to the cell’s interior by second messengers such as cyclic AMP (cAMP), which was once thought to diffuse freely throughout the cytoplasm. Yet cAMP has also become ...

Fabio Anselmi, Victor H. Hernandez, Giulia Crispino, Anke Seydel, Saida Ortolano, Stephen D. Roper, Nicoletta Kessaris, William Richardson, Gesa Rickheit, Mikhail A. Filippov, Hannah Monyer, Fabio ...

This is a preview. Log in through your library . Abstract Acidification of the endosomal pathway is important for ligand and receptor sorting, toxin activation, and protein degradation by lysosomal ...

Zinc acts as second messenger in the cell to propagate extracellular signals Researchers from Japan have shown that zinc can be used by the cell to transduce extracellular signals into cellular ...

G-protein-coupled receptors (GPCRs) are ubiquitous signaling proteins that sit in the membranes of our cells. They’re involved in many physiological processes and, as a result, are frequent drug ...

Signal transduction is the term for the process which causes chemical and physical signals to be transmitted within a cell as a series of molecular events. The most common signal transduction process ...