The meaning of SUBSTANCE is essential nature : essence. How to use substance in a sentence.

SUBSTANCE definition: that of which a thing consists; physical matter or material. See examples of substance used in a sentence.

SUBSTANCE definition: 1. material with particular physical characteristics: 2. an illegal drug: 3. the most important…. Learn more.

Any material that possesses physical properties is called a substance. The word also refers to the gist or main idea of something. If you remember the main point of a lesson, you've got the …

Definition of substance noun in Oxford Advanced Learner's Dictionary. Meaning, pronunciation, picture, example sentences, grammar, usage notes, synonyms and more.

A substance is a solid, powder, liquid, or gas with particular properties. Ethylene glycol is a poisonous substance found in antifreeze. The substance that's causing the problem comes …

A drug, chemical, or other material (such as glue) that one is dependent on or uses habitually and that is often illegal or subject to government regulation: Which substance was he abusing?

the actual matter of a thing as opposed to its appearance:[uncountable] form and substance. Chemistry a particular kind of material, as of a definite chemical composition:[countable] a …

Dec 14, 2025 · substance (countable and uncountable, plural substances) Physical matter; material. quotations

SUBSTANCE meaning: 1 : a material of a particular kind; 2 : a drug that is considered harmful and whose use is controlled by law or made illegal